Chiral micellar electrokinetic chromatography-atmospheric pressure photoionization of benzoin derivatives using mixed molecular micelles

Chiral separation of vinpocetine using cyclodextrin-modified micellar electrokinetic chromatography.

A cyclodextrin-modified micellar electrokinetic chromatography (CD-MEKC) technique has been developed for enantioseparation of vinpocetine using an inexpensive 2-hydroxypropyl-β-CD (HP-β-CD) as the chiral selector (CS). The best chiral separation was achieved using 40 mM HP-β-CD as the CS in 50 mM phosphate buffer (pH 7.0) consisting of 40 mM sodium dodecyl sulfate (SDS) at a separation tempera...

Micellar electrokinetic chromatography.

Chiral Analysis Using Capillary Electrophoresis Coupled to Mass Spectrometry: Development of Novel Modes and Applications Using Molecular Micelles and Surfactant-Bound Monolithic Columns

Micellar electrokinetic chromatography (MEKC) and capillary electrochromatography (CEC) are two of the major capillary electrophoresis (CE) modes that have been interfaced to mass spectrometry (MS) for sensitive and selective analysis of chiral compounds. This research combines these two modes and expands their applications in chiral CE analysis. Chapter 1 is a review of amino acid based molecu...

Modeling The Capacity Factor of Analytes in Micellar Electrokinetic Chromatography Using Computational Descriptors

       A multiple linear regression model is proposed to calculate capacity factor of  analytes using structural features computed using HyperChem software. The  chemical descriptors of analytes were computed using HyperChem software and  regressed against the experimental capacity factors of analytes collected from the  literature. The absolute average percentage deviation (AARD) and individua...

Twenty-five years of micellar electrokinetic chromatography

Micellar electrokinetic chromatography (MEKC), which can separate neutral analytes as well as charged analytes by the capillary electrophoretic technique, was developed in 1982 and the first paper was published in 1984. The authors’ group concentrated their effort into the characterization of MEKC as a separation technique until early 1990s. Most issues in MEKC separations were successfully sol...